Stress accelerates neural degeneration and exaggerates motor symptoms in a rat model of Parkinson's disease
Identifieur interne : 002270 ( Main/Exploration ); précédent : 002269; suivant : 002271Stress accelerates neural degeneration and exaggerates motor symptoms in a rat model of Parkinson's disease
Auteurs : Lori K. Smith [Canada] ; Nafisa M. Jadavji [Canada] ; Keri L. Colwell [Canada] ; S. Katrina Perehudoff [Canada] ; Gerlinde A. Metz [Canada]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2008-04.
English descriptors
- KwdEn :
Abstract
The causes of most cases of Parkinson's disease (PD) are still poorly understood. Here we show that chronic stress and elevated corticosterone levels exaggerate motor deficits and neurodegenerative events in a Parkinson's disease rat model. Animals were tested in skilled and non‐skilled movement while being exposed to daily restraint stress or oral corticosterone treatment. Stress and corticosterone compromised normal motor function and exaggerated motor deficits caused by unilateral 6‐hydroxydopamine lesion of the nigrostriatal bundle. Moreover, stress and corticosterone treatments diminished the ability to acquire compensatory strategies in limb use during skilled reaching and skilled walking. In contrast, lesion control animals were able to significantly improve in the ability of skilled limb use during the repeated test sessions. The exaggerated motor impairments in stress‐treated animals were related to accelerated loss of midbrain dopamine‐producing neurons during the first week postlesion. Correlation analysis revealed a significant connection between loss of tyrosine hydroxylase‐positive cells and increase in Fluoro‐Jade‐positive cells only in stress‐ and corticosterone‐treated animals. Furthermore, stress and elevated corticosterone levels caused greater permanent loss of midbrain neurons than found in non‐treated lesion animals. These findings demonstrate that stress and elevated corticosterone levels can exaggerate nigral neuronal loss and motor symptoms in a rat analogue of PD. It is therefore possible that stress represents a key factor in the pathogenesis of human PD by impeding functional and structural compensation and exaggerating neurodegenerative processes.
Url:
DOI: 10.1111/j.1460-9568.2008.06177.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000C77
- to stream Istex, to step Curation: 000C77
- to stream Istex, to step Checkpoint: 000873
- to stream Main, to step Merge: 002463
- to stream Main, to step Curation: 002270
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stress accelerates neural degeneration and exaggerates motor symptoms in a rat model of Parkinson's disease</title><author><name sortKey="Smith, Lori K" sort="Smith, Lori K" uniqKey="Smith L" first="Lori K." last="Smith">Lori K. Smith</name></author><author><name sortKey="Jadavji, Nafisa M" sort="Jadavji, Nafisa M" uniqKey="Jadavji N" first="Nafisa M." last="Jadavji">Nafisa M. Jadavji</name></author><author><name sortKey="Colwell, Keri L" sort="Colwell, Keri L" uniqKey="Colwell K" first="Keri L." last="Colwell">Keri L. Colwell</name></author><author><name sortKey="Katrina Perehudoff, S" sort="Katrina Perehudoff, S" uniqKey="Katrina Perehudoff S" first="S." last="Katrina Perehudoff">S. Katrina Perehudoff</name></author><author><name sortKey="Metz, Gerlinde A" sort="Metz, Gerlinde A" uniqKey="Metz G" first="Gerlinde A." last="Metz">Gerlinde A. Metz</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B1E720EC02C7A349CC35A4FBA7DBE4DD44E3B255</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1460-9568.2008.06177.x</idno><idno type="url">https://api-v5.istex.fr/document/B1E720EC02C7A349CC35A4FBA7DBE4DD44E3B255/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C77</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C77</idno><idno type="wicri:Area/Istex/Curation">000C77</idno><idno type="wicri:Area/Istex/Checkpoint">000873</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000873</idno><idno type="wicri:doubleKey">0953-816X:2008:Smith L:stress:accelerates:neural</idno><idno type="wicri:Area/Main/Merge">002463</idno><idno type="wicri:Area/Main/Curation">002270</idno><idno type="wicri:Area/Main/Exploration">002270</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Stress accelerates neural degeneration and exaggerates motor symptoms in a rat model of Parkinson's disease</title><author><name sortKey="Smith, Lori K" sort="Smith, Lori K" uniqKey="Smith L" first="Lori K." last="Smith">Lori K. Smith</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Jadavji, Nafisa M" sort="Jadavji, Nafisa M" uniqKey="Jadavji N" first="Nafisa M." last="Jadavji">Nafisa M. Jadavji</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Colwell, Keri L" sort="Colwell, Keri L" uniqKey="Colwell K" first="Keri L." last="Colwell">Keri L. Colwell</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Katrina Perehudoff, S" sort="Katrina Perehudoff, S" uniqKey="Katrina Perehudoff S" first="S." last="Katrina Perehudoff">S. Katrina Perehudoff</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Metz, Gerlinde A" sort="Metz, Gerlinde A" uniqKey="Metz G" first="Gerlinde A." last="Metz">Gerlinde A. Metz</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neuroscience</title><idno type="ISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-04">2008-04</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="2133">2133</biblScope><biblScope unit="page" to="2146">2146</biblScope></imprint><idno type="ISSN">0953-816X</idno></series><idno type="istex">B1E720EC02C7A349CC35A4FBA7DBE4DD44E3B255</idno><idno type="DOI">10.1111/j.1460-9568.2008.06177.x</idno><idno type="ArticleID">EJN6177</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-816X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6‐OHDA</term><term>cell death</term><term>corticosterone</term><term>medial forebrain bundle</term><term>skilled movement</term><term>tyrosine hydroxylase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The causes of most cases of Parkinson's disease (PD) are still poorly understood. Here we show that chronic stress and elevated corticosterone levels exaggerate motor deficits and neurodegenerative events in a Parkinson's disease rat model. Animals were tested in skilled and non‐skilled movement while being exposed to daily restraint stress or oral corticosterone treatment. Stress and corticosterone compromised normal motor function and exaggerated motor deficits caused by unilateral 6‐hydroxydopamine lesion of the nigrostriatal bundle. Moreover, stress and corticosterone treatments diminished the ability to acquire compensatory strategies in limb use during skilled reaching and skilled walking. In contrast, lesion control animals were able to significantly improve in the ability of skilled limb use during the repeated test sessions. The exaggerated motor impairments in stress‐treated animals were related to accelerated loss of midbrain dopamine‐producing neurons during the first week postlesion. Correlation analysis revealed a significant connection between loss of tyrosine hydroxylase‐positive cells and increase in Fluoro‐Jade‐positive cells only in stress‐ and corticosterone‐treated animals. Furthermore, stress and elevated corticosterone levels caused greater permanent loss of midbrain neurons than found in non‐treated lesion animals. These findings demonstrate that stress and elevated corticosterone levels can exaggerate nigral neuronal loss and motor symptoms in a rat analogue of PD. It is therefore possible that stress represents a key factor in the pathogenesis of human PD by impeding functional and structural compensation and exaggerating neurodegenerative processes.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Smith, Lori K" sort="Smith, Lori K" uniqKey="Smith L" first="Lori K." last="Smith">Lori K. Smith</name></noRegion><name sortKey="Colwell, Keri L" sort="Colwell, Keri L" uniqKey="Colwell K" first="Keri L." last="Colwell">Keri L. Colwell</name><name sortKey="Jadavji, Nafisa M" sort="Jadavji, Nafisa M" uniqKey="Jadavji N" first="Nafisa M." last="Jadavji">Nafisa M. Jadavji</name><name sortKey="Katrina Perehudoff, S" sort="Katrina Perehudoff, S" uniqKey="Katrina Perehudoff S" first="S." last="Katrina Perehudoff">S. Katrina Perehudoff</name><name sortKey="Metz, Gerlinde A" sort="Metz, Gerlinde A" uniqKey="Metz G" first="Gerlinde A." last="Metz">Gerlinde A. Metz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002270 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002270 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B1E720EC02C7A349CC35A4FBA7DBE4DD44E3B255
|texte= Stress accelerates neural degeneration and exaggerates motor symptoms in a rat model of Parkinson's disease
}}
| This area was generated with Dilib version V0.6.29. |  |